This happens when you try to access a directory that is not setup in Apache2
Its easy to fix….
sudo nano /etc/apache2/apache2.conf
add these lines
<Directory /var/www/”mysite”>
Options FollowSymLinks
Allow Override All
Order deny,allow
Allow from all
</directory>
Cntl-o to save, Cntl-X to exit Nano
systemctl restart apache2
Test to ensure it working, if its not working, check that you entered the correct directory, fix and restart as necessary